LABORATORIO B19                     

J. Arenas, Y. Campos, B. Bornstein, R. Ribacoba, M.A. Martín, J.C. Rubio, F. Santorelli, M. Zeviani, S. DiMauro and R. Garesse (1999) “A double mutation (A8296G and G8363A) in the mtDNA tRNA^lys gene associated with MERRF” Neurology  52: 377-382.

I. Ruiz de Mena, M.A. Fernández-Moreno, B. Bornstein, L.S. Kaguni and R. Garesse (1999) “Structure and regulated expression of d-aminolevulinate synthase gene fromDrosophila melanogaster” J. Biol. Chem. 274: 37321-37328.

I. Ruiz de Mena, E. Lefai, R. Garesse and L.S. Kaguni (2000) “Regulation of mitochondrial single-stranded DNA-binding protein gene expression links nuclear and mitochondrial DNA replication in Drosophila” J. Biol. Chem. 275: 13628-13636.

E. Lefai, M.A. Fernández-Moreno, L.S. Kaguni and R. Garesse (2000) “Structure of the highly compact mitochondrial DNA polymerase genomic region of Drosophila melanogaster: evolutionary and functional implications” Insect Mol. Biol. 9: 315-322.

M. A. Fernández-Moreno, B. Borstein, Y. Campos J. Arenas and R. Garesse (2000) “About the pathogenic role of point mutations affecting the translational initiation codon of mitochondrial genes”. Mol. Genet. Metabol. 70: 238-240.

M.A. Fernández-Moreno, I. Ruiz de Mena and R. Garesse (2000) “Regulation of mitochondrial biogenesis during development and cell differentiation” Current Topics in Biochem. Res., 2, 127-136.

E. Lefai, M. Calleja, I. Ruiz de Mena, A.T. Lagina III, L.S. Kaguni and R. Garesse (2000) “Overexpression of the catalytic subunit of DNA polymerase produces mitochondrial DNA depletion in Drosophila melanogaster ” Mol. Gen. Genet. 264, :37-46.

E. Lefai, M.A. Fernández-Moreno, A. Alahari, L.S. Kaguni and R. Garesse (2000) “The expression of the catalytic and accessory subunits of the mitochondrial DNA polymerase are differentially regulated in Drosophila melanogaster. J. Biol. Chem. 275: 33123-33133.

M. A. Fernández-Moreno, B. Borstein, N. Petit and R. Garesse (2000) “The pathophysiology of mitochondrial biogenesis: towards four decades of mitochondrial DNA research” Mol. Genet. Metabol. 71: 481-495.

R. Garesse and C.G. Vallejo (2001) “Animal mitochondrial biogenesis and function: a regulatory cross-talk between two genomes” Gene 263: 1-16

Y. Campos, J. Gámez, A. García, A.L. Andreu, J.C. Rubio, M.A. Martín, P. del Hoyo, C. Navarro, C.Cervera, R. Garesse and J. Arenas. (2001) “A new mtDNA mutation in the tRNA^Leu(UUR) gene associated with ocular myopathy” Neuromuscular Disord. 11:477-480

Y. Campos, A. García-Redondo, M.A Fernández-Moreno, M. Martínez-Pardo, G. Goda, J.C. Rubio, M.A. Martín, P. del Hoyo, A. Cabello, B. Bornstein, R. Garesse and J. Arenas (2001) “Early onset multisystem mitochondrial disorder due to a nonsense mutation in the mitochondrial DNA COX II gene” Ann. Neurol.  50: 409-413.

P. de la Peña , B. Bornstein, P. del Hoyo, M.A. Fernández-Moreno, M.A. Martín, Y. Campos, C. Gómez-Escalonilla, J.A. Molina, A. Cabello, J. Arenas and R. Garesse (2001) “Mitochondrial dysfunction associated with mutations in the Notch gene of Drosophila and the Notch3 gene of CADASIL patients” Neurology  57: 1235-1238)

C. Ugalde, P. Ochoa, M. L. Pérez, M. A. Fernández-Moreno, M. Calleja, A. Alahari, L. S. Kaguni and R. Garesse (2001)  “Identification of a proximal promoter region critical for the expression of theb-F1-ATPase gene during Drosophila melanogaster development” Mitochondrion 1: 225-236.

B. Bornstein, J. A. Mas, M. A. Fernández-Moreno, Y. Campos, M. A. Martín, P. del Hoyo, J. C. Rubio, J. Arenas and R. Garesse (2002). “The A8296G mutation associated to several mitochondrial diseases does not cause mitochondrial dysfunction in cybrid cell lines" Hum Mutat 19: 234-239.

J. Arenas, M.A. Fernández-Moreno, J.A. Molina, V. Fernandez, P. del Hoyo, Y. Campos, P. Calvo, M.A. Martin, A. Garcia, T. Moreno, A. Martinez-Salio, B. Bornstein, F. Bermejo, A. Cabello, and R. Garesse (2003) “Myoglobinuria and COX deficiency in a patient taking cerivastatin and gemfibrozil”. Neurology 60: 124-126.

Sanchez-Alcazar JA, Schneider E, Hernandez-Munozz I, Ruiz-Cabello J, Siles-Rivas E, Borstein B, Brea G, Arenas J, Garesse R, Solis-Herruzo JA, Knox A, Navas P.(2003) “Reactive oxygen species mediate the down-regulation of mitochondrial transcripts and proteins by Tumor Necrosis Factor-alphain L929 cells”. Biochem J. (en prensa).