Autophagy is an intracellular degradation mechanism essential for cell homeostasis, differentiation and development. Autophagy has a major impact on various pathologies such as Alzheimer´s and aging. Our laboratories use different model systems to study the molecular basis and cellular mechanisms of rare diseases and their relationship with autophagy. These models include the yeast Saccharomyces cerevisiae, the social amoeba Dictyostelium discoideum, and mammalian cells in culture. Modeling rare disease in these simple organisms could open up new therapeutic possibilities.


Laboratory for the study of autophagy-related rare diseases

IIB, Instituto de Investigaciones Biomédicas Alberto Sols

Arturo Duperier 4



Modeling rare diseases in Yeast, Dictyostelium and human cells     cells

                                               Major lines of research


             Molecular mechanism of the autophagic machinery and its regulation.


Molecular basis of rare diseases BPAN and ChAc associated to WIPI and VPS13 proteins



Associated lab at UCM