Autophagy is an intracellular degradation mechanism essential for cell survival and maintenance of cellular homeostasis, differentiation and development. Recent research has highlighted the impact of autophagy in neurodegenerative diseases and aging. We are still far from fully understanding the molecular mechanism of autophagy and its regulation, which is essential for the use of autophagy as a therapeutic target. Our laboratories use different model systems to study autophagy. These models include the yeast Saccharomyces cerevisiae, the social amoeba Dictyostelium discoideum and mammalian cells in culture. Our multidisciplinary approach allow a deep level of analysis of the proteins involved in the mechanism of autophagy with an emphasis in those related to human disease.


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Laboratory for the study of the molecular mechanisms of autophagy

IIB, Instituto de Investigaciones Biomédicas

Arturo Duperier 4

28029-Madrid

Spain

Autophagy in Yeast, Dictyostelium and human cells

Lines of Research:

  

Identification of new proteins of the autophagic machinery and its regulation

   

Function of Vmp1 in the origin of autophagosomes and regulation of PtdIns3P signalling

   

Study of the function of VPS13 protein family. The possible role of autophagy in the associated diseases: Chorea-acanthocytosis and Cohen Syndrome


WIPI proteins in autophagy and its role in the rare disease BPAN