Autophagy is an intracellular degradation mechanism essential for cell survival and maintenance of cellular homeostasis, differentiation and development. Recent research has highlighted the impact of autophagy in neurodegenerative diseases and aging. We are still far from fully understanding the molecular mechanism of autophagy and its regulation, which is essential for the use of autophagy as a therapeutic target. During the last years our laboratory has been developing the use of Dictyostelium discoideum as a model in biomedical research. Its simplicity and genetic tractability is combined with a remarkable similarity with animal cells. We are characterizing new genes involved in autophagy and the knowledge obtained in this model system is used to advance in the function of their homologous human genes using mammalian cell culture.

























 

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IIB, Instituto de Investigaciones Biomédicas

Arturo Duperier 4

28029-Madrid

Spain

E-mail: rescalante@iib.uam.es

Español-English

Autophagy in Dictyostelium and human cells

Lines of Research:

  

Identification of new proteins of the autophagic machinery and its regulation


   

Function of Vmp1 in the origin of autophagosomes and regulation of PtdIns3P signalling

   

Study of the function of VPS13 protein family. The possible role of autophagy in the associated diseases: Chorea-acanthocytosis and Cohen Syndrome