Grupo de Neurobiología de la audición. IIB

PUBLICACIONES SELECCIONADAS

Cediel R, Riquelme R, Contreras J, Diaz A, Varela-Nieto I. Sensorineural hearing loss in insulin-like growth factor I-null mice: a new model of human deafness. Eur J Neurosci. 2006 Jan;23(2):587-590. (PMID: 16420467)
Varela-Nieto I., Hartl M.A., Gorospe I. and León Y . "Anti-apoptotic actions of insulin-like growth factors: lessons from development and implications in neoplastic cell transformation.". Curr. Phar. Des. 2006.
Diaz-Casares A, Leon Y, de la Rosa EJ, Varela-Nieto I. Regulation of vertebrate sensory organ development: a scenario for growth hormone and insulin-like growth factors action. Adv Exp Med Biol. 2005;567:221-42. Review (PMID: 16370141)
Jones DR, Paneda C, Villar AV, Alonso A, Goni FM, Butikofer P, Brodbeck U, Shepherd PR, Varela-Nieto I. Phosphorylation of glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its properties as a substrate for phospholipases. FEBS Lett. 2005 Jan 3;579(1):59-65. (PMID: 15620691)
Cediel Algobia, R.; Sánchez de la muela, M.; Calderón Sánchez, A.; Murillo Cuesta, S.; Fernández Martín, A.; García Fernández, P,. "Diagnóstico de sordera en mascotas mediante potenciales evocados.". Consulta de difusión veterinaria, 2005 MAY; 13 (120). 73-80. ISSN: 11350598.
Marí, M.; Colell, A.; Morales, A.; Pañeda, C.; Varela-Nieto, I.; García-Ruiz, C.; Fernyez-Checa, J.C. "Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis". J. Clin. Invest. 113(6): 895-904. (2004). (PMID: 15067322).
León Y. and Varela-Nieto I. Glycosylphosphatidylinositols cleavage products in signal transduction. Lipases and Phospholipases in Drug Development. Ed Müller G. and Petry S. Wiley-VCH. Weinheim. 2004. Pg. 101-119. ISBN 3-527-30677-3.
Varela-Nieto, I.; Morales-Garcia, J.A.; Vigil, P.; Diaz-Casares, A.; Gorospe, I.; Syhez-Galiano, S.; Cañon, S.; Camarero, G.; Contreras, J.; Cediel, R.; Leon, Y. "Trophic effects of insulin-like growth factor-I (IGF-I) in the inner ear". Hear. Res. 196(1-2): 19-25. (2004). (PMID: 15464297).
Alsina B, Giraldez F, Varela-Nieto I. "Growth factors and early development of otic neurons: interactions between intrinsic and extrinsic signals". Curr Top Dev Biol. 2003;57:177-206. PMID: 14674481
Camarero, G.; Leon, Y.; Gorospe, I.; De Pablo, F.; Alsina, B.; Giraldez, F.; Varela-Nieto, I. "Insulin-like growth factor 1 is required for survival of transit-amplifying neuroblasts and differentiation of otic neurons". Dev. Biol. 262(2): 242-253. (2003). (PMID: 14550788).
Frago, L.M.; Cañón, S.; de la Rosa, E.J.; León, Y.; Varela-Nieto, I. "Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I". J. Cell. Sci. 116(Pt 3): 475-486. (2003). (PMID: 12508109).
Varela-Nieto, I.; de la Rosa, E.J.; Valenciano, A.I.; León, Y. "Cell death in the nervous system: lessons from insulin and insulin-like growth factors". Mol. Neurobiol. 28(1): 23-50. (2003). (PMID: 14514984).
Balboa, M.A.; Varela-Nieto, I.; Killermann Lucas, K.; Dennis, E.A. "Expression and function of phospholipase A(2) in brain". FEBS. Lett. 531(1): 12-17. (2002). (PMID: 12401195).
Camarero, G.; Villar, M.A.; Contreras, J.; Fernyez-Moreno, C.; Pichel, J.G.; Avendaño, C.; Varela-Nieto, I. "Cochlear abnormalities in insulin-like growth factor-1 mouse mutants". Hear. Res. 170(1-2): 2-11. (2002). (PMID: 12208536).
Paneda C, Gorospe I, Herrera B, Nakamura T, Fabregat I, Varela-Nieto I. "Liver cell proliferation requires methionine adenosyltransferase 2A mRNA up-regulation". Hepatology. 2002 Jun;35(6):1381-91. PMID: 12029623.
Colombaioni, L.; Frago, L.M.; Varela-Nieto, I.; Pesi, R.; Garcia-Gil, M. "Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells". Neurochem Int. 2002 Apr;40(4):327-36. (PMID: 11792463).
Paneda C, Villar AV, Alonso A, Goni FM, Varela F, Brodbeck U, Leon Y, Varela-Nieto I, Jones DR.. "Purification and characterization of insulin-mimetic inositol phosphoglycan-like molecules from grass pea (Lathyrus sativus) seeds.". Mol Med. 2001 Jul;7(7):454-60. (PMID: 11683370).
Camarero G, Avendano C, Fernandez-Moreno C, Villar A, Contreras J, de Pablo F, Pichel JG, Varela-Nieto I. "Delayed inner ear maturation and neuronal loss in postnatal Igf-1-deficient mice.". J Neurosci. 2001 Oct 1;21(19):7630-41. (PMID: 11567053).
Frago LM, Paneda C, Fabregat I, Varela-Nieto I. "Short-chain ceramide regulates hepatic methionine adenosyltransferase expression". J Hepatol. 2001 Feb;34(2):192-201. (PMID: 11281546).
Pimentel, B.; Sanz, C.; Varela-Nieto, I.; Rapp, U.R.; De Pablo, F.; de La Rosa, E.J. "c-Raf regulates cell survival and retinal ganglion cell morphogenesis during neurogenesis". J. Neurosci. 20(9): 3254-3262. (2000). (PMID: 10777790).
Jones, D.R.; Varela-Nieto, I. "Diabetes and the role of inositol-containing lipids in insulin signaling". Mol Med.1999 Aug;5(8):505-14. Review. (PMID):10501653
Sanz, C.; León, Y.; Canon,S.; Alvarez,L.; Giraldz,F.; Varela-Nieto, I."Pattern of expression of the jun family of transcription factors during the early development o the inner ear: implications in apoptosis". J Cell Sci. 1999 Nov ; 112(Pt 22): 396-74. (PMID: 10547357).
Sanz, C.; León, Y.; Troppmair, J.; Rapp, U.R.; Varela-Nieto, I. "Strict regulation of c-Raf kinase levels is required for early organogenesis of the vertebrate inner ear". Oncogene. 18(2): 429-437. (1999). (PMID: 9927199).
Varela-Nieto, I.; Silos-Santiago, I. "Introduction to structural and functional studies on nerve growth factor". Microsc. Res. Tech. 45(4-5): 2206. (1999). (PMID: 10383111).
Villar, A.V.; Alonso, A.; Pañeda, C.; Varela-Nieto, I.; Brodbeck, U.; Goñi, F.M. "Towards the in vitro reconstitution of caveolae. Asymmetric incorporation of glycosylphosphatidylinositol (GPI) and gangliosides into liposomal membranes". FEBS. Lett. 457(1): 71-74. (1999). (PMID: 10486566).
Frago, L.M.; León, Y.; de la Rosa, E.J.; Gómez-Muñoz, A.; Varela-Nieto, I. "Nerve growth factor and ceramides modulate cell death in the early developing inner ear". J. Cell. Sci. 111 ( Pt 5): 549-556. (1998). (PMID: 9454729).
Frago LM, Gimenez A, Rodriguez EN, Varela-Nieto I. "Pattern of methionine adenosyltransferase isoenzyme expression during rat liver regeneration after partial hepatectomy.". FEBS Lett. 1998 Apr 24;426(3):305-8. (PMID: 9600256).
León, Y.; Sanz, C.; Giraldez, F.; Varela-Nieto, I. "Induction of cell growth by insulin and insulin-like growth factor-I is associated with Jun expression in the otic vesicle". J. Comp. Neurol. 398(3): 323-332. (1998). (PMID: 9714146).
Jones DR, Varela-Nieto I."The role of glycosyl-phosphatidylinositol in signal transduction". Int J Biochem Cell Biol. 1998 Mar;30(3):313-26. Review. (PMID: 9611774).
Villar, A.V.; Goñi, F.M.; Alonso, A.; Jones, D.R.; León, Y.; Varela-Nieto, I. "Phospholipase cleavage of glycosylphosphatidylinositol reconstituted in liposomal membranes". FEBS. Lett. 432(3): 150-154. (1998). (PMID: 9720914).
Caro HN, Kunjara S, Rademacher TW, Leon Y, Jones DR, Avila MA, Varela-Nieto I. "Isolation and partial characterisation of insulin-mimetic inositol phosphoglycans from human liver". Biochem Mol Med. 1997 Aug;61(2):214-28. (PMID: 9259987).
Gomez-Munoz A, Frago LM, Alvarez L, Varela-Nieto I. "Stimulation of DNA synthesis by natural ceramide 1-phosphate". Biochem J. 1997 Jul 15;325 ( Pt 2):435-40. (PMID: 9230125).
Jones DR, Avila MA, Sanz C, Varela-Nieto I. "Glycosyl-phosphatidylinositol-phospholipase type D: a possible candidate for the generation of second messengers". Biochem Biophys Res Commun. 1997 Apr 17;233(2):432-7. (PMID: 9144552).
Sanchez-Bueno A, Greenwood MR, Varela-Nieto I, Marrero I, Gil B, Mato JM. "Inositol-phosphoglycan inhibits calcium oscillations in hepatocytes by reducing calcium entry". Cell Calcium. 1997 Feb;21(2):125-33. (PMID: 9132295).
León, Y.; Vazquez, E.; Sanz, C.; Vega, J.A.; Mato, J.M.; Giraldez, F.; Represa, J.; Varela-Nieto, I. "Insulin-like growth factor-I regulates cell proliferation in the developing inner ear, activating glycosyl-phosphatidylinositol hydrolysis and Fos expression". Endocrinology. 136(8): 3494-3503. (1995). (PMID: 7628386).

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Instituto de Investigaciones Biomédicas "Alberto Sols"
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